Derpixon on Twitter @condylonucla Very sweet work Despondency is a common mental illness affecting millions of folk worldwide. Despondency may show as continuous sorrow, diminished curiosity, tiredness without cause, or trouble focusing. Therapy for despondency might involve pharmaceuticals, therapy, physical activity, and self-care practices. It's important to look for guidance and participate in steps to manage depression successfully. Remember, there is help available in overcoming depression.